Safe threshold of capillary blood glucose for predicting early future neonatal hypoglycaemia in babies born to mothers with gestational diabetes mellitus, an observational, retrospective cohort study

This study validated a method requiring only 10 microlitres of serum and found high agreement between fingerstick capillary samples and venous serum for monitoring twelve antibiotics. The results suggest capillary serum sampling is a feasible, minimally invasive alternative that avoids the haematocrit effect associated with whole blood microsampling.

Feasibility verification of fingerstick capillary microsampling replacing venipuncture for therapeutic drug monitoring of 12 antibiotics using a rapid LC-MS/MS assay — Chen et al., Talanta (paywalled) · source ↗

• blood
• liquid
• capillary
• validation
• venous-agreement
• pediatric
• tdm
• antimicrobials

In 91 children and adults, capillary C-peptide taken with the TAP device matched venous sampling with 100% sensitivity and specificity for a clinically relevant level, 200 pmol/L or above, with r = 0.996. 63% preferred it to a needle against 7% who preferred the needle, and same-day bruising was 5.5% versus 34.8% after a venous draw.

Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes — Besser et al., Diabetes Care · source ↗

• blood
• liquid
• yourbio
• capillary
• pediatric
• venous-agreement
• acceptability
• validation

In at-home and trial settings, a wet capillary device reliably collected a median ~450 µL with a 4.4% failure rate; 88% of adults preferred self-collection over venipuncture, with lower pain.

Feasibility, acceptability and safety of a device for self-collecting capillary blood in clinical trials — Dasari et al., PLOS ONE · source ↗

• dct
• acceptability
• blood
• self-collection
• capillary
• pediatric
• liquid
• validation

Adolescents collecting blood microsamples at home achieved varying success rates across six devices, with Minicollect tubes performing poorest. The confirmation that visual inspection alone was insufficient, by analytical variability, underscores the need for robust quality assessment before deploying any device in decentralised trials.

Self-Sampling by Adolescents at Home: Assessment of the Feasibility to Successfully Collect Blood Microsamples by Inexperienced Individuals — Boffel et al., The AAPS journal (paywalled) · source ↗

• blood
• liquid
• dried
• capillary
• vams
• dbs
• neoteryx-mitra
• self-collection
• acceptability
• pediatric
• dct

The paper records that the TAP II devices used for the infant draws were provided by YourBio Health, and that capillary serum was collected from babies as young as two months: the smallest patients sampled, without a heel prick or a venepuncture.

Durability of anti-spike antibodies in infants after maternal COVID-19 vaccination or natural infection — Shook, Edlow et al., JAMA · source ↗

• blood
• liquid
• yourbio
• capillary
• pediatric
• serology