Late-night salivary cortisol and cortisone should be the initial screening test for Cushing's syndrome
Mohamed et al.
The finding, in our words
In a retrospective cohort, late-night salivary cortisol had 95% sensitivity and 91% specificity, while late-night salivary cortisone had 86% sensitivity and 100% specificity; using an optimal cut-off of 14.5 nmol/L, late-night salivary cortisone achieved 95.2% sensitivity and 100% specificity with an AUC of 0.997, supporting simultaneous measurement of both as first-line screening for suspected Cushing's syndrome, and because saliva collection is non-invasive and can be done at home, it is suitable for patient-centric decentralised diagnostics.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
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