2025 · The Indian journal of medical research · open access
HPV-DNA testing from self-sampled menstrual blood using M-strip: A proof-of-concept study on feasibility & acceptance of a novel biosampling method
Chandra et al.
The finding, in our words
Self-collection of menstrual blood using the M-strip was feasible and highly acceptable to women, and hr-HPV DNA results from menstrual blood showed 100% concordance with direct cervical smears, supporting its potential use in decentralised cervical screening.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Non-invasive HPV self-sampling kits such as first-void urine and menstrual blood devices may increase screening participation among non-Western ethnic minority women by addressing cultural beliefs about virginity and body autonomy.
Hald et al., Journal of racial and ethnic health disparities · source ↗
In a population-based study of 566 women in Puerto Rico, self-collection of anal, cervical, and oral specimens for HPV testing achieved an 83.4% response rate with high acceptability: over 98% of participants understood the methods and more than 50% felt comfortable with them. This demonstrates the feasibility of decentralised, patient-centric HPV surveillance using self-collection, supporting wider implementation of remote STI screening programmes.
Ortiz et al., Puerto Rico health sciences journal (paywalled) · source ↗
A study of 2500 women found 99.0% agreement between first-void urine and vaginal self-sampling for HPV detection using Cobas4800, with 98.1% of participants preferring urine. Although conducted in a resource-limited setting which may limit generalisability, these results support urine as a viable sample type for decentralised, patient-centric screening.
First-void urine and self-collected vaginal swabs showed similar sensitivity and specificity to clinician-collected cervical samples for high-risk HPV detection across two real-time PCR assays, supporting their use as decentralised, patient-collected alternatives; most women preferred first-void urine for regular cervical screening.
A et al., Journal of gynecologic oncology (paywalled) · source ↗
This randomised sub-study found return rates of 10.4% for Colli-Pee, 10.1% for FLOQSwabs and 7.4% for Evalyn-Brush. All devices yielded sufficient DNA with low invalid rates, but the authors noted the study was limited by low overall participation.
Hempel et al., Archives of gynecology and obstetrics · source ↗