2026 · African journal of laboratory medicine · paywalled
Evaluating the utility of storage solutions to preserve nucleic acid integrity at ambient temperature in South Africa
Moshoma et al.
The finding, in our words
The study found that DNA in blood samples stored at room temperature using commercial solutions or as dried blood spots maintained acceptable integrity for up to 90 days, supporting their use in decentralised settings where cold chain storage is not feasible. RNA integrity was below the acceptable range, and high temperatures caused degradation, highlighting limitations for ambient transport in hot climates.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The DPB-LF device collected capillary blood and generated dried plasma that showed strong correlation with wet plasma for four traumatic brain injury biomarkers, with R² values between 0.83 and 0.99. Samples remained stable at 4 °C and predicted cranial lesions on computed tomography with areas under the curve of 0.70–0.76, providing a patient‑centric microsampling approach that removes cold‑chain requirements for decentralised TBI diagnostics.
Kobeissy et al., Journal of advanced research (paywalled) · source ↗
EDTA or phosphoric acid-EDTA pretreatment of dried blood spot cards markedly improved amino acid stability under heat and humidity, maintaining accuracy for several days. This advance supports reliable self-collection and postal transport of samples for metabolic disorder monitoring in decentralised settings.
Wilson et al., Molecular genetics and metabolism (paywalled) · source ↗
Dried blood spot sampling coupled with LC-HRMS identified and quantified 37 synthetic opioids with detection limits of 0.05 to 0.2 ng/mL. The method proved stable over seven days at ambient temperature and simplified collection, storage, and transport compared with frozen venous blood, which is pertinent for decentralised toxicology screening.
Mestria et al., Forensic science international (paywalled) · source ↗
In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.
Levens et al., Clinical Pharmacokinetics (paywalled) · source ↗
Guidance on capillary-to-plasma conversion: method- and analyte-specific clinical validation with paired capillary–venous samples before reporting plasma-equivalent results.
Boffel et al., Therapeutic Drug Monitoring (paywalled) · source ↗