2026 · Clinica chimica acta; international journal of clinical chemistry · paywalled
Enhancing creatinine detection: Innovative biosensors for monitoring kidney function
Heidari et al.
The finding, in our words
Nanomaterial-based biosensors can enhance sensitivity and specificity for creatinine detection in blood and urine, and integrating them into wearables may enable continuous patient monitoring to support personalised kidney disease management.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
The study found that a heat-treated probiotic formulation did not significantly improve sleep scores in the full cohort but did modulate endocrine markers, showing up-regulated nocturnal melatonin and improved daytime orexin levels, with a tendency toward reduced nocturnal salivary cortisol. Benefits were more pronounced in participants with higher baseline insomnia severity, suggesting the intervention may be most useful for symptomatic populations.
A scoping review of 52 studies found most were high-quality RCTs using CGM, metabolomics and microbiome analysis in endurance athletes, yet evidence linking these biomarkers to performance, recovery or long-term health remains insufficient. This gap between biomarker discovery and clinical validation must be closed before these decentralised tools can guide precision nutrition.
Menstrual blood offers a noninvasive, patient-centric matrix for detecting endometriosis, cervical cancer, and hormonal disorders through self-collected samples. Wearable in-pad biosensors enabling real-time monitoring and long-term tracking could transform fertility evaluation and early disease detection, though standardisation and large-scale validation remain critical gaps.
Shafiq et al., Annals of medicine and surgery · source ↗
In progressive multiple sclerosis, higher serum neurofilament light chain levels were associated with reduced daily step counts from wearables, while higher step counts were linked to lower sNfL. A ten percent increase in steps corresponded to a 0.015 decrease in sNfL z-score, suggesting rising sNfL may predict subsequent mobility decline.
Joseph et al., Annals of clinical and translational neurology (paywalled) · source ↗