2021 · Journal of laboratory physicians · open access
Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma spp. Coinfection in an HIV-Positive Homosexual Man
Khullar et al.
The finding, in our words
First-void urine and anatomical-site swabs identified multiple STI coinfections in an HIV-positive homosexual man, with rectal swabs detecting all four pathogens. The case supports decentralised screening of high-risk groups for concurrent sexually transmitted infections.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
First-void urine samples showed significantly higher detection rates of HPV-specific IgG antibodies compared to midstream urine, confirming the necessity of capturing the initial stream. The study found no significant difference between 10 mL and 20 mL collection volumes, indicating flexibility in device specifications for self-collection.
Van Caesbroeck et al., Human vaccines & immunotherapeutics · source ↗
First-void urine PCR identified Ureaplasma urealyticum in 19% of symptomatic men, alongside other pathogens, confirming that patient-collected urine samples provide valid diagnostic results for STI screening outside traditional clinical settings.
The bivalent HPV vaccine showed 100 percent effectiveness against vaccine types 16 and 18 seven years post-vaccination in Thai schoolgirls, but only 32.8 percent effectiveness against other high-risk types, indicating limited cross-protection. The study used first-void urine self-collection for HPV DNA detection, demonstrating a scalable, non-invasive approach for vaccine effectiveness monitoring in decentralised settings.
Nilyanimit et al., Human vaccines & immunotherapeutics · source ↗
In a review of 91 human adenovirus-associated urethritis cases, dysuria occurred in 84% and meatitis in 34% of patients, with adenovirus type D being the most common subtype identified in first-void urine and urethral smears. Multiplex PCR screening for adenovirus in non-gonococcal urethritis can help establish accurate diagnoses and avoid unnecessary treatments.
Idigoras et al., Sexually transmitted diseases (paywalled) · source ↗
The study found comparable seropositivity for Chlamydia trachomatis and Toxoplasma gondii among male partners of infertile couples in Odisha, with 28 per cent showing anti-Chlamydia IgA and 28 per cent anti-Toxoplasma IgM antibodies. This demonstrates that first-void urine and seminal fluid can detect relevant infections, supporting their use in decentralised fertility screening programmes.
Naik et al., The Indian journal of medical research · source ↗