Biomarkers and Detection Platforms for Human Health and Performance Monitoring: A Review
Sim et al.
The finding, in our words
The review summarises current biosensor technologies for human health monitoring via wearable sensors and minimally invasive biomarkers from sweat, urine and interstitial fluid, observing that commercial devices mainly track physical traits while biochemical sensing provides richer information, and identifies key technical hurdles for field deployment.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The review finds that lab-on-chip liquid biopsy technologies are sufficiently mature for distanced cancer screening and follow-up, enabling patient-centric sample collection that reduces exposure risks during pandemics.
Ferrara et al., Biosensors & bioelectronics · source ↗
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
Wearable biochemical monitoring requires a complete measurement chain that integrates quality-controlled biofluid sampling, sensor fusion and metadata capture to convert raw sensor outputs into clinically valid digital biomarkers.
Salivary cortisol is suitable as an adjunctive measure in decentralised monitoring, with lateral-flow assays providing rapid low-cost discrete measurements and wearable platforms enabling higher-frequency collection but facing biofouling and calibration challenges. Suitability requires validation in authentic saliva against reference methods, not merely low detection limits.
The review examines microneedle patches, flexible electronic skins and textile-based sensors for continuous inflammation monitoring, discussing their design, operation and data processing methods, and identifies future development opportunities for these wearable platforms.