A new approach with dried plasma spots: a rapid determination of antidepressants and antipsychotics by fast GC-MS
de Gouveia et al.
The finding, in our words
The method was validated with limits of quantitation 20–60 ng/mL and accuracy 87.8–112.2%, and was applied to 102 human plasma samples from suspected poisoning cases with 90.2% positivity, offering a cheap, easy, fast approach for toxicological emergency laboratories.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The analysis indicates that dried blood spots and volumetric absorptive microsampling enable minimally invasive monitoring of prohibited substances, with volumetric absorptive microsampling offering improved quantitative reliability over traditional dried spots.
VAMS gave near‑quantitative recovery for cadmium and lead in human blood and correlated strongly with venous sampling, with pre‑cleaning improving correlation and lowering background lead, supporting its use for decentralised biomonitoring of these toxic elements.
Gutknecht et al., Environmental monitoring and assessment (paywalled) · source ↗
A validated two-step LC-MS/MS protocol can identify 91 prohibited doping agents from a single dried blood spot collected on either cellulose cards or volumetric absorptive microsampling devices. This demonstrates robust multi-analyte screening from capillary blood, supporting decentralised anti-doping programmes where venous sampling is impractical.
This review highlights that microsampling techniques such as dried blood spots and volumetric absorptive microsampling offer superior alternatives to traditional sampling for the mass spectrometry detection of prohibited substances in anti-doping analysis. It provides guidance on selecting appropriate analytical methods and sample pretreatment strategies to ensure sensitive detection and reliable storage conditions.
Maykar et al., Critical reviews in analytical chemistry (paywalled) · source ↗
Dried blood spot sampling coupled with LC-HRMS identified and quantified 37 synthetic opioids with detection limits of 0.05 to 0.2 ng/mL. The method proved stable over seven days at ambient temperature and simplified collection, storage, and transport compared with frozen venous blood, which is pertinent for decentralised toxicology screening.
Mestria et al., Forensic science international (paywalled) · source ↗