The association between rest-activity rhythms and glycemic markers: the US National Health and Nutrition Examination Survey, 2011-2014
Xiao et al.
The finding, in our words
In a diverse US population, weaker rest-activity rhythmicity derived from 24-hour actigraphy was associated with impaired glycaemic control and a 2.37-fold higher odds of diabetes. This supports actigraphy as a digital biomarker for metabolic risk stratification in remote monitoring.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
In progressive multiple sclerosis, higher serum neurofilament light chain levels were associated with reduced daily step counts from wearables, while higher step counts were linked to lower sNfL. A ten percent increase in steps corresponded to a 0.015 decrease in sNfL z-score, suggesting rising sNfL may predict subsequent mobility decline.
Joseph et al., Annals of clinical and translational neurology (paywalled) · source ↗
The High-Definition Oncology feasibility study in 30 women with metastatic cancer demonstrated high adherence to biospecimen collection (97.4% plasma, 80.7% stool) and wearable monitoring (70–95% of days captured for activity, heart rate, sleep, and oxygen saturation). This establishes a viable framework for decentralised, multimodal data collection in oncology to support individualised treatment models.
Garma et al., JCO precision oncology (paywalled) · source ↗
Wearing-off symptoms during natalizumab treatment in multiple sclerosis correlate with fatigue but not with inflammatory or neurodegenerative biomarkers, suggesting they are not markers of disease activity. Passive wearable monitoring detected subtle end-of-cycle motor declines and dynamic activity features that aligned with fatigue, indicating potential for digital biomarkers to serve as remote endpoints in decentralised neurological care.
Masanneck et al., Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (paywalled) · source ↗
The study demonstrated that longitudinal remote monitoring using wearable sleep electroencephalography, actigraphy, and self-collected saliva samples is feasible in older adults with mild cognitive impairment or dementia, with high retention and data completeness rates over eight weeks.
A patient with RET fusion positive pancreatic neuroendocrine carcinoma had early improvement in smartwatch readings after starting selpercatinib, which preceded rises in serum tumour markers and CT changes confirming tumour response. Wearable signals may therefore flag efficacy sooner than conventional methods in targeted cancer therapy.
Deschler-Baier et al., NPJ precision oncology · source ↗