2025 · Photodiagnosis and photodynamic therapy · paywalled
Salivary attenuated total reflectance-fourier transform infrared spectroscopy combined with chemometric analysis: A potential point-of-care approach for chronic kidney disease screening
Tangwanichgapong et al.
The finding, in our words
Dried saliva analysed by ATR-FTIR and chemometrics discriminated ESRD from controls with 87.5–100% accuracy, 75–100% sensitivity and 100% specificity, offering a non‑invasive point‑of‑care screening option for CKD.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
This systematic review of 67 studies involving 34,739 kidney disease patients found dried blood microsampling was mainly used for immunosuppressant therapeutic drug monitoring and kidney function assessment. The approach offered cost savings, was preferred by patients for home self-collection, and provides a patient-centric opportunity to upscale longitudinal sampling and reduce participation bias in decentralised kidney disease research.
Lamond et al., Journal of clinical laboratory analysis · source ↗
The review summarises 2017–2023 advances in measuring proteins from dried matrix spots by LC-MS, including blood, urine and other fluids. It describes ‘smart sampling’ that embeds cell separation, digestion and antibody capture into the collection step, which streamlines decentralised proteomic workflows.
Reubsaet & Halvorsen, Journal of separation science · source ↗
This study of 184 individuals showed that home collection of dried blood spots and saliva can identify genetic polymorphisms linked to cardiac serum markers. Seven SNPs associated significantly with markers such as Apo B, LDL Direct, and hsCRP, while a polygenic risk score correlated strongly with NT-proBNP (r²=0.82, P=.03) and ox-LDL (r²=0.94, P=.005). These results indicate decentralised genetic sampling could enable early cardiovascular risk assessment and identify patients requiring closer serological monitoring.
The review summarises dried saliva spot method developments between 2014 and 2021, noting saliva’s convenience for children and disabled persons as an alternative matrix to serum for therapeutic drug monitoring and disease diagnosis, while emphasising that sample preparation and validation challenges remain before widespread decentralised adoption.
Han et al., Journal of pharmaceutical analysis · source ↗