2024 · International journal of molecular sciences · open access
Renal Cell Carcinoma Discrimination through Attenuated Total Reflection Fourier Transform Infrared Spectroscopy of Dried Human Urine and Machine Learning Techniques
Buhas et al.
The finding, in our words
Dried urine ATR-FTIR spectroscopy distinguished renal cell carcinoma from healthy controls with 82% accuracy using principal component analysis combined with linear discriminant analysis. Creatinine signal intensity was significantly lower in cancer cases, suggesting a potential decentralised screening tool, though further validation against other urological diseases is required.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Frequent dried blood spot sampling detected early changes in beta-cell function more effectively than mixed-meal tolerance tests or urine ratios, supporting its potential as a decentralised monitoring tool for clinical trials.
Dunseath et al., Diabetes care (paywalled) · source ↗
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
The dried urine spot device showed strong agreement with liquid urine across three clinical chemistry analysers and stable performance across temperatures, enabling decentralised ambient collection for albumin-to-creatinine ratio.
Olausson et al., Clinical chemistry and laboratory medicine (paywalled) · source ↗
Urinary NGAL measured from dried urine spots collected on Capitainer qDBS discs correlated strongly with liquid urine measurements (R² = 0.98) and showed good agreement, with a median recovery of 95.4%. This validates volumetric dried urine microsampling for decentralised kidney injury biomarker testing in paediatric populations.
Sütterlin et al., Biomedicines (paywalled) · source ↗
Blood-based matrices such as serum and dried blood spots offer direct access to circulating analytes, overcoming key detection limitations of traditional urine testing for agents like erythropoiesis-stimulating drugs and peptide hormones. Capillary microsampling technologies provide simplified collection workflows that support the expansion of multi-matrix anti-doping and biological passport programmes.