Liquid Biopsy for Pancreatic Cancer Detection Using Infrared Spectroscopy
Sala et al.
The finding, in our words
ATR-FTIR spectroscopy of dried blood serum distinguished pancreatic cancer from healthy controls with 92% sensitivity and 88% specificity (AUC 0.95), and from symptomatic non-malignant controls with over 75% sensitivity and specificity (AUC 0.83). This proof-of-concept demonstrates potential for a simple, minimally invasive liquid biopsy approach to improve early detection of pancreatic cancer in decentralised settings.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A prospective study of 1384 individuals developed an 18-small RNA signature (miLung) for lung cancer detection, achieving an area under the curve of 0.86 in discovery and 0.83 in validation cohorts. Diagnostic performance increased with tumour stage, and dried blood spot collection suggests feasibility for home self-collection.
Sikosek et al., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (paywalled) · source ↗
The authors developed a protocol that extracts and size-selects cell-free DNA from 50 μL dried blood spots, detecting tumour-derived ctDNA in patients with melanoma and ovarian carcinoma. The fragment-size profile matched plasma DNA, suggesting that dried blood spots could support decentralised cancer monitoring and novel trial designs.
Heider et al., Clinical chemistry (paywalled) · source ↗
In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.
Levens et al., Clinical Pharmacokinetics (paywalled) · source ↗
Guidance on capillary-to-plasma conversion: method- and analyte-specific clinical validation with paired capillary–venous samples before reporting plasma-equivalent results.
Boffel et al., Therapeutic Drug Monitoring (paywalled) · source ↗
The analysis indicates that dried blood spots and volumetric absorptive microsampling enable minimally invasive monitoring of prohibited substances, with volumetric absorptive microsampling offering improved quantitative reliability over traditional dried spots.