2022 · Journal of human hypertension · open access
Home blood pressure monitors owned by participants in a large decentralised clinical trial in hypertension: the Treatment In Morning versus Evening (TIME) study
Anbarasan et al.
The finding, in our words
In a large decentralised hypertension trial of 21,104 adults, nearly half used their own home blood pressure monitors for remote monitoring, but 18.7% of identifiable devices lacked validation against standardised protocols despite costing substantially less than validated models. This reveals a critical gap in device quality for decentralised trials relying on patient-owned equipment.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This study validated a low-cost 3D-printed smartphone attachment and paper sensor for measuring glucose, uric acid and cholesterol in saliva, demonstrating high correlation with standard ELISA results in a small clinical cohort. The authors suggest this platform offers a scalable solution for decentralised diabetes management by balancing sensitivity with affordability.
Yang et al., Biosensors & bioelectronics (paywalled) · source ↗
Wearable-derived digital biomarkers have been accepted by regulatory agencies as endpoints in clinical trials for Duchenne muscular dystrophy, showing their potential to support decentralised diagnostics through patient-centric monitoring. This matters because it enables more sensitive and continuous assessment of disease progression outside clinical settings.
Ma et al., Neurology and therapy (paywalled) · source ↗
A systematic review of 19,704 articles, analysing 45 trials and 117 documents, found wide heterogeneity in decentralised clinical trial designs. The authors caution that there is currently insufficient evidence to confirm which decentralised methods are most effective for trial recruitment, retention, or overall cost.
Rogers et al., British Journal of Clinical Pharmacology (paywalled) · source ↗
A machine learning model called Remote Control was trained on 2685 blood samples to predict change due to instability, enabling accurate calibration of results to approximate the time zero value at collection. With calibration, unprocessed whole blood could be transported for up to 9 days under ambient conditions and temperatures between 3.4 and 47.4 degrees Celsius, achieving agreement with CLIA TEa between 98.1 and 100 per cent and expanding the catalog of tests available for at-home collection.
O'Meara et al., Analytical chemistry (paywalled) · source ↗