Blood Microsampling to Monitor Metabolic Profiles During Physical Exercise

Plasma lipidomes from self-collected upper-arm capillary blood were statistically indistinguishable from paired venous plasma, most classes at r=0.95–0.99, validating at-home capillary self-collection for lipidomics.

Comparison of capillary and venous plasma lipidomes: validation of self-collected blood for plasma lipidomics — Hameed et al., J. Lipid Research · source ↗

• venous-agreement
• blood
• metabolome
• self-collection
• capillary
• liquid
• validation
• biomarkers

This study found that dried blood microsamples, particularly those collected with the Mitra device, provided metabolic profiles comparable or superior to conventional plasma, supporting their use as a viable alternative for untargeted metabolomics.

Toward minimally invasive metabolomics: GC-MS metabolic fingerprints of dried blood microsamples in comparison to plasma — Marques de Sá E Silva et al., The Analyst (paywalled) · source ↗

• vams
• venous-agreement
• neoteryx-mitra
• blood
• dbs
• metabolome
• dried
• capillary
• validation

Capillary blood collection using volumetric absorptive microsampling demonstrated equivalent quantification of principal colonic polyphenol metabolites compared with matched venous plasma across a six-hour period following barley biscuit consumption. The technique successfully captured the pharmacokinetic profiles over 48 hours, confirming VAMS as a reliable alternative to venepuncture for dietary biomarker monitoring.

Finger-prick blood sampling using volumetric absorptive microsampling (VAMS) method for monitoring the main (poly)phenolic metabolites in human blood after barley biscuit intake — Cortijo-Alfonso et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled) · source ↗

• vams
• venous-agreement
• neoteryx-mitra
• blood
• metabolome
• dried
• capillary
• validation
• biomarkers

Capillary blood collected by fingerstick or microblade devices produced metabolite profiles that were virtually identical to venous samples when the same biofluid type was compared. This validation study demonstrates that inexpensive microsampling systems can deliver comparable metabolomics data, supporting their use in decentralised diagnostics.

Quantitative comparison of whole blood, plasma and serum metabolomes across different blood collection methods — Zubkowski et al., Metabolomics : Official journal of the Metabolomic Society (paywalled) · source ↗

• blood
• capillary
• validation
• venous-agreement
• metabolome

Microsampling enables less invasive, patient-centric self-collection of capillary blood for remote monitoring of metabolites and lipids, overcoming conventional venipuncture constraints. Recent device innovations address dried blood spot limitations, particularly haematocrit and volume variations, expanding decentralised applications in population health, drug discovery and multi-omics research.

Revolutionizing Blood Collection: Innovations, Applications, and the Potential of Microsampling Technologies for Monitoring Metabolites and Lipids — Bossi et al., Metabolites · source ↗

• multimodal
• blood
• dbs
• metabolome
• self-collection
• haematocrit
• dried
• capillary
• validation
• biomarkers
• multi-omics