2026 · Cancer control : journal of the Moffitt Cancer Center · open access
Barriers and Facilitators of Programmatic HPV Testing: Lessons Learnt From Two In-Depth Provincial Case Studies Ten Years After the Jujuy Demonstration Project in Argentina
Paolino et al.
The finding, in our words
Ten years after a demonstration project, HPV testing programmes in two Argentine provinces faced barriers of reduced national support, interrupted test supply, limited financing, and challenges maintaining laboratory centralisation and self-collection services. Facilitators included stable staff, provincial leadership, guideline adherence, and high technology acceptability, highlighting real-world implementation challenges for decentralised screening.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A study of 2500 women found 99.0% agreement between first-void urine and vaginal self-sampling for HPV detection using Cobas4800, with 98.1% of participants preferring urine. Although conducted in a resource-limited setting which may limit generalisability, these results support urine as a viable sample type for decentralised, patient-centric screening.
First-void urine and self-collected vaginal swabs showed similar sensitivity and specificity to clinician-collected cervical samples for high-risk HPV detection across two real-time PCR assays, supporting their use as decentralised, patient-collected alternatives; most women preferred first-void urine for regular cervical screening.
A et al., Journal of gynecologic oncology (paywalled) · source ↗
This randomised sub-study found return rates of 10.4% for Colli-Pee, 10.1% for FLOQSwabs and 7.4% for Evalyn-Brush. All devices yielded sufficient DNA with low invalid rates, but the authors noted the study was limited by low overall participation.
Hempel et al., Archives of gynecology and obstetrics · source ↗
Self-sampling for HPV testing using urine and swab devices achieved high DNA detection rates, 92.1-99.7%, and very high participant acceptance, 99.1%, in a primary care population, supporting decentralised screening in low-resource settings.
This meta-analysis found that urine self-sampling for HPV detection had significantly lower sensitivity for high-grade lesions compared to vaginal and cervical samples, though specificity remained comparable. Despite the reduced diagnostic accuracy, the non-invasive and acceptable nature of urine sampling supports its use as a decentralised option to improve screening uptake.
Nath et al., Journal of medical screening (paywalled) · source ↗