Association of Mycoplasma genitalium with infertility in North Indian women

The study found comparable seropositivity for Chlamydia trachomatis and Toxoplasma gondii among male partners of infertile couples in Odisha, with 28 per cent showing anti-Chlamydia IgA and 28 per cent anti-Toxoplasma IgM antibodies. This demonstrates that first-void urine and seminal fluid can detect relevant infections, supporting their use in decentralised fertility screening programmes.

Seropositivity of <i>Chlamydia trachomatis & Toxoplasma gondii</i> among male partners of infertile couples in Odisha, India: A facility-based exploratory study — Naik et al., The Indian journal of medical research · source ↗

• first-void
• blood
• sti
• serology
• fertility
• urine

First-void urine from women with recurrent spontaneous abortion showed that Chlamydia trachomatis infection was associated with upregulated SOD2 and downregulated SOD1 expression, alongside increased oxidative stress markers 8-hydroxyguanosine and 8-isoprostane, suggesting a role for antioxidant imbalance and ROS detoxification pathways in RSA pathogenesis.

Aberrant gene expression of superoxide dismutases in Chlamydia trachomatis-infected recurrent spontaneous aborters — Ray et al., Scientific reports · source ↗

• first-void
• sti
• fertility
• urine
• biomarkers

The study identified differential expression of urine-circulating microRNAs in five Chlamydia trachomatis-positive women with recurrent spontaneous abortion versus controls, with miR-16 showing 4.3-fold upregulation. This supports first-void urine as a viable non-invasive specimen for molecular screening of infection-related reproductive complications in decentralised settings.

Differential expression of urine-circulating micro-RNAs in Chlamydia trachomatis-induced recurrent spontaneous aborters — Ray et al., Microbial pathogenesis (paywalled) · source ↗

• urine
• first-void
• fertility
• sti
• biomarkers

Among 250 infertile Iranian men, self-collected first-void urine enabled decentralised detection of Chlamydia trachomatis, yet infection status showed no correlation with sperm chromatin condensation or DNA fragmentation. The study validates first-void urine for remote STI screening in fertility assessment, while indicating sperm quality markers are independent of Chlamydia infection.

Effects of Chlamydia trachomatis infection on sperm chromatin condensation and DNA integrity — Dehghan Marvast et al., Andrologia (paywalled) · source ↗

• urine
• first-void
• fertility
• serology
• sti

In 250 Iranian infertile couples followed for 24 months, detection of Chlamydia trachomatis DNA in first-void urine, semen or serum antibodies did not predict tubal factor infertility, pregnancy rate or outcome. This indicates that patient-collected first-void urine screening for these organisms may have limited clinical utility in fertility assessment.

Relationship between Chlamydia trachomatis and Mycoplasma genitalium infection and pregnancy rate and outcome in Iranian infertile couples — Dehghan Marvast et al., Andrologia (paywalled) · source ↗

• blood
• urine
• first-void
• fertility
• serology
• sti