2014 · Annals of Internal Medicine · open access
Lee et al.
Pooling 19 studies, FIT for colorectal cancer showed ~0.79 sensitivity and ~0.94 specificity: a moderately sensitive, highly specific single-sample stool screen, dependent on the positivity cut-off.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
2026
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
Integrating Microsampling in Human Biomonitoring: Methodologies, Regulatory Frameworks, and Case Study Insights — Rajamani & Poongavanam, Critical reviews in analytical chemistry (paywalled) · source ↗
2025
This study found that stool samples self-collected on cards showed high correlation and agreement with ethanol-fixed samples for metagenomic sequencing, with negligible differences in microbial diversity. The results support the use of stool cards as a cost-effective alternative for decentralised sampling in epidemiologic studies, despite minor variations in individual species abundance.
Comparing the Metagenomic Performance of Stools Collected from Custom Cards and 95% Ethanol in Epidemiologic Studies — Kuntz et al., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (paywalled) · source ↗
2018
A systematic review and meta-analysis of interventions to raise colorectal cancer screening participation, including mailed outreach of home collection kits.
Evaluation of Interventions Intended to Increase Colorectal Cancer Screening Rates in the United States: A Systematic Review and Meta-analysis — Dougherty et al., JAMA Internal Medicine (paywalled) · source ↗
2025
This study compared OMNIgene Gut tubes and FTA cards for stool collection in a deployed setting, finding that OMNIgene yielded higher nucleic acid concentrations while both methods detected the majority of microbial genera. The authors conclude that distinct microbial abundance profiles between the two methods necessitate standardised protocols for field research.
Field expedient stool collection methods for gut microbiome analysis in deployed military environments — Kok et al., mSphere · source ↗
2025
Researchers validated a UHPLC-MS/MS assay for citrinin in capillary blood collected with Neoteryx Mitra VAMS devices, plus feces and urine, achieving quantification limits of 0.05 ng/mL. The study derived human toxicokinetic parameters from 48-hour sample collection after a single oral dose, demonstrating that microsampling enables robust population-level exposure assessment for mycotoxins.
Derivation of Human Toxicokinetic Parameters and Chemical-Specific Adjustment Factor of Citrinin Through a Human Intervention Trial and Hierarchical Bayesian Population Modeling — Visintin et al., Toxins · source ↗