Accelerometer-based sleep metrics and gut microbiota during adolescence: Association findings from a Brazilian population-based birth cohort
Carpena et al.
The finding, in our words
In a Brazilian birth cohort, longer sleep duration and higher sleep efficiency at age 11 were associated with higher gut microbial alpha-diversity and lower Bacteroidetes abundance at age 12, suggesting sleep influences gut microbiota composition in adolescence.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Self-reported insomnia and excessive sleepiness were associated with depletion of Eubacterium sp. CAG:251, whereas higher actigraphy-measured sleep efficiency increased its prevalence and longer wake after sleep onset reduced it. These findings suggest that subjective and objective sleep disturbances converge on specific gut microbes, supporting the use of stool sampling and wearable actigraphy in decentralised diagnostics.
In a one-week virtual home clinic with 134 participants, 86 per cent returned saliva and 84 per cent returned stool, and most components were feasible and acceptable despite device and logistical challenges. This supports decentralised, patient-centric self-collection of non-blood biospecimens for research.
The Human Phenotype Project enrolled 28,000 participants in a deep-phenotyping cohort that combines blood and microbiome sampling with continuous glucose and sleep monitoring. An AI model trained on dietary and glucose data predicted disease onset more accurately than existing methods, showing how integrating continuous digital signals with multi-omic data can support personalised risk assessment for decentralised diagnostics.
Reicher et al., Nature medicine (paywalled) · source ↗
In healthy Chinese older adults, higher gut microbiota richness was associated with better objective sleep quality measured by actigraphy, independent of subjective sleep reports and covariates. Specific bacterial taxa were tentatively linked to sleep metrics, showing how combining wearable sleep monitoring with home stool collection can reveal clinically relevant gut-brain axis relationships to support decentralised diagnostics in ageing populations.
Probiotic supplementation improved wearable-measured sleep duration in healthy adults, demonstrating that continuous digital sleep metrics can detect clinically meaningful changes from gut microbiota interventions. The trial showed concurrent shifts in stool microbiome composition, short-chain fatty acids and cortisol, linking gut-brain axis modulation to objective sleep outcomes.