A survey of Australian consumers' and dentists' perceptions of saliva as a biofluid for periodontitis diagnosis
Sun et al.
The finding, in our words
This survey found that whilst consumers were optimistic about using saliva for periodontitis diagnosis, many clinicians remained uncertain about the accuracy of the method. The results indicate a need for further evidence and education to support the adoption of decentralised saliva sampling workflows.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Participants preferred the Omnigene and Zymo oral swabs for comfort and ease of use, whilst the Omnigene device yielded the highest median bacterial DNA concentration compared to the other devices. The results indicate that the choice of self-collection device impacts both patient acceptability and DNA yield for oral microbiome analysis.
The study determined that an at-home saliva collection protocol using the passive drool method was feasible for Black women with histories of abuse, with 84% of participants completing at least one full day of adherent sampling. While the decentralised approach yielded usable cortisol data, women with histories of forced sex exposure showed lower protocol adherence scores.
This study demonstrated that a fully remote genome sequencing study using self-collected dried blood spots and buccal swabs is feasible for individuals with Prader-Willi syndrome, with all participants completing the study and reporting the process was easy despite being lengthy. The design successfully returned actionable genetic findings, including those related to blood clot formation, to participants.
In a one-week virtual home clinic with 134 participants, 86 per cent returned saliva and 84 per cent returned stool, and most components were feasible and acceptable despite device and logistical challenges. This supports decentralised, patient-centric self-collection of non-blood biospecimens for research.
Capillary blood self-collected with the VAMS device showed 100 per cent agreement with serum for detecting SARS-CoV-2 S RBD antibodies in participants with known past infection, and saliva showed slightly lower but high agreement; agreement was good to almost perfect in those without known antibodies, and most participants found finger prick easy while half found the microsampler easy, supporting decentralised serosurveillance.