An ecological study of objective rest-activity markers of lithium response in bipolar-I-disorder
Scott et al.
The finding, in our words
In 70 outpatients with bipolar I disorder, 21-day actigraphy revealed that stable and regular circadian rest-activity patterns were significantly associated with positive lithium response. These findings suggest continuous wearable monitoring of rest-activity rhythms could serve as an objective digital biomarker to aid treatment stratification.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
In progressive multiple sclerosis, higher serum neurofilament light chain levels were associated with reduced daily step counts from wearables, while higher step counts were linked to lower sNfL. A ten percent increase in steps corresponded to a 0.015 decrease in sNfL z-score, suggesting rising sNfL may predict subsequent mobility decline.
Joseph et al., Annals of clinical and translational neurology (paywalled) · source ↗
The High-Definition Oncology feasibility study in 30 women with metastatic cancer demonstrated high adherence to biospecimen collection (97.4% plasma, 80.7% stool) and wearable monitoring (70–95% of days captured for activity, heart rate, sleep, and oxygen saturation). This establishes a viable framework for decentralised, multimodal data collection in oncology to support individualised treatment models.
Garma et al., JCO precision oncology (paywalled) · source ↗
Wearing-off symptoms during natalizumab treatment in multiple sclerosis correlate with fatigue but not with inflammatory or neurodegenerative biomarkers, suggesting they are not markers of disease activity. Passive wearable monitoring detected subtle end-of-cycle motor declines and dynamic activity features that aligned with fatigue, indicating potential for digital biomarkers to serve as remote endpoints in decentralised neurological care.
Masanneck et al., Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (paywalled) · source ↗
Patients with metastatic cancer who recorded ≤3013 steps/day during the 14‑day post‑discharge period had substantially higher rates of 90‑day unplanned readmission (73% versus 13%) and mortality (47% versus 9%) than more active patients. Wearable‑derived mobility is a promising decentralised digital biomarker for risk stratification after hospital discharge, but requires external validation before guiding supportive care.
Akdogan et al., Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (paywalled) · source ↗
Remote patient monitoring was feasible in pre-lung transplant candidates: 80 percent of participants entered data for at least four weeks, though adherence varied by modality (pulse oximetry 82 percent, spirometry 69 percent, activity tracking 31 percent). Daily step count declined during the median 11-week waiting period, and home-based walking distance was lower than on-site performance, indicating that remote monitoring can detect clinical changes but needs automated device integration to improve data capture and clinical utility.
Wickerson et al., Clinical transplantation · source ↗