Cross-sectional adherence with the multi-target stool DNA test for colorectal cancer screening in a medicaid population
Miller-Wilson et al.
The finding, in our words
A retrospective analysis of laboratory data found that adherence to a home-collected multi-target stool DNA test was 51.3% among Medicaid enrollees, 54.6% in Managed-Medicaid and 38.9% in Fee-For-Service. This shows that navigation-supported stool self-collection is a viable patient-centric option for decentralised screening, though the study was limited by its retrospective design.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This study found that stool samples self-collected on cards showed high correlation and agreement with ethanol-fixed samples for metagenomic sequencing, with negligible differences in microbial diversity. The results support the use of stool cards as a cost-effective alternative for decentralised sampling in epidemiologic studies, despite minor variations in individual species abundance.
A pilot RCT found home self-sampling tools substantially increased screening uptake for colorectal cancer, 75% vs 13%, and cervical cancer, 79% vs 8%, versus standard reminders among underserved patients, with abnormal findings in a quarter of returned tests. The study was limited by small sample size and short follow-up.
The study demonstrated that a decentralised healthcare model using self-collected blood in stool tests achieved high adherence and early detection rates for colorectal cancer. It also showed a favourable cost-benefit ratio compared to the standard costs of treating advanced disease.
Non-invasive self-sampling of anal colorectal mucus following defecation provides a patient-acceptable alternative to traditional stool collection for diagnosing colorectal cancer and inflammatory bowel disease. This emerging approach allows reliable measurement of diagnostic biomarkers to improve screening compliance.
A systematic review and meta-analysis of interventions to raise colorectal cancer screening participation, including mailed outreach of home collection kits.