2026 · Journal of voice : official journal of the Voice Foundation · paywalled
Artificial Intelligence-Related Voice and Speech Biomarkers of Alzheimer's Disease: A Systematic Review
Mairesse et al.
The finding, in our words
AI-driven speech analysis shows high diagnostic performance for distinguishing Alzheimer's disease from healthy controls but is less reliable for mild cognitive impairment; clinical translation is limited by methodological bias and lack of external validation, indicating a need for large-scale, multicenter, longitudinal studies.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Wearable-derived digital biomarkers have been accepted by regulatory agencies as endpoints in clinical trials for Duchenne muscular dystrophy, showing their potential to support decentralised diagnostics through patient-centric monitoring. This matters because it enables more sensitive and continuous assessment of disease progression outside clinical settings.
Ma et al., Neurology and therapy (paywalled) · source ↗
Wearable biochemical monitoring requires a complete measurement chain that integrates quality-controlled biofluid sampling, sensor fusion and metadata capture to convert raw sensor outputs into clinically valid digital biomarkers.
Healthy older adults performed similarly on functional capacity tests whether delivered by computer or cloud-based tablet, with only a five per cent speed improvement on the iPad version of one test. This supports the feasibility of migrating digital clinical assessments to remote cloud-based delivery for decentralised trials without compromising validity.
Harvey et al., Schizophrenia research. Cognition · source ↗
Patient-reported questionnaires remain the most frequently used tools for chemotherapy-induced peripheral neuropathy, while wearable sensors and digital technologies are emerging but suffer from considerable heterogeneity in design and validation. The review concludes that standardised and validated diagnostic tools are urgently needed for routine clinical practice.
This review assesses wearable sensors for the continuous biochemical monitoring of body fluids such as sweat, saliva and interstitial fluid, confirming their potential for decentralised healthcare through pilot trials. It emphasises that successful clinical translation depends on large-scale validation and the integration of ethical and sociocultural considerations.