2023 · Journal of medical Internet research · open access
Accuracy of a Standalone Atrial Fibrillation Detection Algorithm Added to a Popular Wristband and Smartwatch: Prospective Diagnostic Accuracy Study
Selder et al.
The finding, in our words
The Fibricheck algorithm added to a Biostrap wristband detected atrial fibrillation with 98 percent sensitivity and 96 percent specificity, while on a Fitbit Ionic it achieved 97 percent sensitivity and 100 percent specificity, each against twelve-lead ECG. Unclassifiable readings occurred in twelve percent of Biostrap and five percent of Fitbit measurements, showing high accuracy for AF detection with a standalone photoplethysmography algorithm on consumer wrist devices.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A direct-to-participant, multichannel recruitment strategy enrolled 34,244 older adults into a virtual trial testing an Apple Watch based heart health programme with electrocardiogram and irregular rhythm notification features, achieving broad geographic and gender diversity but under-representing non-White ethnic groups.
Analysis of six studies revealed that decentralised clinical trial elements enhanced data completeness by enabling direct access to medical records, although this introduced a significant burden for data abstraction. The results suggest that decentralised approaches are not a universal solution but provide specific metrics that can help design fit-for-purpose trials.
In progressive multiple sclerosis, higher serum neurofilament light chain levels were associated with reduced daily step counts from wearables, while higher step counts were linked to lower sNfL. A ten percent increase in steps corresponded to a 0.015 decrease in sNfL z-score, suggesting rising sNfL may predict subsequent mobility decline.
Joseph et al., Annals of clinical and translational neurology (paywalled) · source ↗
Wearable-derived digital biomarkers have been accepted by regulatory agencies as endpoints in clinical trials for Duchenne muscular dystrophy, showing their potential to support decentralised diagnostics through patient-centric monitoring. This matters because it enables more sensitive and continuous assessment of disease progression outside clinical settings.
Ma et al., Neurology and therapy (paywalled) · source ↗
Higher plasma BDNF levels were associated with a lower prevalence of sarcopenia and better kinetic and spatiotemporal gait performance in older adults.
Zhang et al., Journal of cachexia, sarcopenia and muscle · source ↗