Cancer decentralized clinical trials in the Veterans Health Administration

In four crew members, capillary volumetric absorptive microsampling caught altered acetaminophen pharmacokinetics in flight: Cmax rose to 43,300 ng/mL from 9,110 before flight and clearance fell to 3,890 mL/h from 16,200, pointing to toxicity risk at standard dosing; four people only, but a case for microsampling where no clinic can reach.

Volumetric Absorptive Microsampling During Spaceflight for Analysis of Acetaminophen Pharmacokinetics in Whole Blood — Mampre et al., Journal of clinical pharmacology · source ↗

• blood
• capillary
• vams
• tdm
• dct

The study observed favourable trends in the accrual of participants residing far from the site and those from underrepresented groups following the implementation of a decentralised clinical trial program.

A Multiregional Decentralized Clinical Trial Program to Improve Access — Haddad et al., JAMA network open · source ↗

• dct

The Australian Teletrial Programme improved patient access to trials and workforce capability through harmonised processes and training, but broader implementation is limited by workforce turnover, complex approvals, and variable leadership engagement. This highlights that systemic policy and governance support are critical for the sustainable integration of decentralised trial models.

Whole-of-system approach for program implementation: Lessons from the Australian Teletrial Program — Sabesan et al., Journal of telemedicine and telecare (paywalled) · source ↗

• dct

This review suggests that decentralised clinical trials in oncology can improve patient participation and equity but face significant regulatory, logistical and digital hurdles. It concludes that these trials offer a flexible model dependent on specific clinical contexts rather than a universal replacement for conventional methods.

From site-centered to patient-centered: Promises and challenges of decentralized clinical trials in oncology — Gentile et al., Critical reviews in oncology/hematology (paywalled) · source ↗

• oncology
• dct

The study found that although participants preferred patient-centric microsampling devices for home use, the agreement with venous plasma for measuring CRP and cytokines was inconsistent, indicating that further validation is required before these methods replace standard venipuncture.

Limited agreement of cytokines and CRP through patient-centric microsampling compared to venipuncture in healthy adults — Tuttle et al., Bioanalysis (paywalled) · source ↗

• dct
• venous-agreement
• acceptability
• blood
• dbs
• self-collection
• dried
• biomarkers